The final stage of improvements to a roundabout on Flensburg Way will involve temporary overnight road closures on the A582 and B5253.
Work is well underway at the junction of Flensburg Way and Penwortham Way, Farington – known locally as the 'Tank roundabout'.
Lancashire County Council began work last year to add capacity to the A582 and reduce delays on this key route in and out of Preston, and across South Ribble.
The upgrading of the A582 is one of the four major road schemes included in the Preston, South Ribble and Lancashire City Deal.
The following overnight road closures are planned to take place from 8pm to 5am:
• 22 August to 23 August - Penwortham Way, towards Penwortham and Preston only.
• 23 August to 26 August - Flensburg Way, heading towards Bamber Bridge and the M65, closure in both directions.
• 24 August to 27 August - Lane closures on the roundabout.
• 30 August to 31 August - Flensburg Way, heading from Leyland.
• 31 August to 5 September - Penwortham Way, towards Penwortham and Preston, closure in both directions.
• 5 September to 12 September - Flensburg Way, towards Bamber Bridge and the M65, closure in both directions.
• 12 September to 13 September - Lane closures on the roundabout.
Diversions suitable for all vehicles will be signed throughout.
For details of road closures during August and September, and any changes due to bad weather or other circumstances, please check the A582 webpage on the City Deal website.
Phill Wilson, City Deal project manager, said: "This improvement work is part of City Deal, which is increasing capacity along this major route through South Ribble, helping people to travel around the area and increasing access to the motorway network and Preston city centre.
"We would advise people to allow more time to travel in this area, as they may be some minor delays during these closures.
"We apologise in advance for the disruption to traffic, as well as any inconvenience to local residents and businesses. We are doing everything we can to keep this to a minimum.
"This necessary work will help to improve journey times in the long term, and we are grateful for people's patience while it is on-going."